If set to true then Y will start from top, else Y will start from bottom (Default is false)
Note that the library under the hood of this plugin does not support flipping the coordinates like this so its done on higher level. If you suspect something not working right then simply switch this property to false.
It is perfectly valid to flip this property back and forth within the same Page, as the property is taken into account at the time when each drawing function is called. So some functions could be called with it on and others with it off.
The SetLocation method on the Destination class does not support flipping coordinate systems since that method does not know anything about the Page class or its settings.